Sites Matching In The Mirna Seed Region Including All K Mer 8mer Download Scientific Diagram
In this study, we found that rs in the seed region of miR4513 associates with fasting glucose, LDLcholesterol and total cholesterol, blood pressure and risk of coronary artery disease We idAnalysis of experimentally validated miRNA targets demonstrated a similar trend, indicating a putative conserved mechanistic feature of seed regiondependent targeting mechanism These observations may prove useful as parameters for offtarget prediction algorithms and improve siRNA 'specificity' design rules
Seed region of mirna
Seed region of mirna- To characterize the basepairing patterns of miRNAtarget interaction, we searched for overrepresented sequence elements in all the targets discovered for each miRNA For most of the top expressed miRNAs, highly enriched sequence motifs emerged as complementary to the extended miRNA seed region (nucleotides 1–8 of miRNA) (Fig 4A and S7 Fig)TargetScan predicts biological targets of miRNAs by searching for the presence of 8mer, 7mer, and 6mer sites that match the seed region of each miRNA As an option, only conserved sites are predicted Also identified are sites with mismatches in the seed region that are compensated by conserved 3' pairing and centered sites
Mirbase An Overview Sciencedirect Topics
Is the miRNA seed region always located between the 2 and the 7 nucleotides?Krek et al, 05) More than onethird 31 miRNAs with SNPs in Their Seed Region Are Significantly Enriched in Clusters In total, we identified 1879 SNPs in 1226 (436%) human miRNA seed regions after mapping genetic variation onto human miRNA seed regions based on the genomic coordinates of SNPs in dbSNP human Build 147 and miRNAs in miRBase release 21 (Table S1)
Seed region of mirnaA mismatch tolerance test assay, based on pools of transgenic strains, revealed that target hybridization to nucleotides of the seed region, at the 5′ end of an miRNA, was sufficient to induce moderate repression of expression In contrast, pairing to the 3′ region of the miRNA was not critical for silencingThe seed Importance of seed and seedless matches Early studies on miRNA target recognition revealed nearperfect (contiguous) and conserved, WatsonCrick complementarity at the 5' miRNA end, which was called the "seed region" The seed is a 6–8 nt substring within the first 8 nucleotides, starting from the 5' miRNA endMiRNAs regulate the gene expression by binding to the mRNA The seed sequence is essential for the binding of the miRNA to the mRNA The seed sequence or seed region is a conserved heptametrical sequence which is mostly situated at positions 27 from the miRNA 5´end Even though base pairing of miRNA and its target mRNA does not match perfect, the "seed sequence"
Seed region of mirnaのギャラリー
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry | Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
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 Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |  Mirna Therapeutics A New Class Of Drugs With Potential Therapeutic Applications In The Heart Future Medicinal Chemistry |
Sense strand), also called the 'seed region', is complementary to the 3′ untranslated regions (UTRs) of multiple mRNAs, causing degradation of their associated transcripts 8,9 To improve the interpretation of RNAi datasets and to help minimize followup experimental efforts, it is important to identify transcripts that areSeed matches located in each gene region is shown in Figure 1 The seed match type of 1t8Mi2 contains 6 bits of WatsonCrick pairing and 2 bits of mismatches from position 1 to 8 in the 59 of miRNA, and was used as a negative control for SNR calculation It is observed that the SNR of this seed match type is closest to 10 among all types of
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